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Chemical Structure : GSM-2
Catalog No.: PC-62913Not For Human Use, Lab Use Only.
GSM-2 is a second-generation γ-secretase modulator (GSM) that only decreases Aβ42 (IC50=65.2 nM), while inversely increasing Aβ38 and having no effect on β-CTF and Aβ40 levels.
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GSM-2 is a second-generation γ-secretase modulator (GSM) that only decreases Aβ42 (IC50=65.2 nM), while inversely increasing Aβ38 and having no effect on β-CTF and Aβ40 levels.
GSM-2 significantly ameliorates memory deficits in Tg2576 mice and does not affect normal cognition in wild-type mice.
| M.Wt | 467.5 | |
| Formula | C23H31F6NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mitani Y, et al. J Neurosci. 2012 Feb 8;32(6):2037-50.
2. Robertson AS, et al. Eur J Pharmacol. 2017 Oct 5;812:104-112.
3. Mitani Y, et al. J Neurochem. 2013 May;125(3):465-72.
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