Chemical Structure : GSTO1 inhibitor A13
CAS No.:
GSTO1 inhibitor A13
Catalog No.: PC-25752Not For Human Use, Lab Use Only.
GSTO1 inhibitor A13 is a potent, selective, covalent and metabolically stable glutathione S-transferase omega 1 (GSTO1) inhibitor with IC50 of 457 nM, targets GSTO1 at Cys32.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
GSTO1 inhibitor A13 is a potent, selective, covalent and metabolically stable glutathione S-transferase omega 1 (GSTO1) inhibitor with IC50 of 457 nM, targets GSTO1 at Cys32.
A13 effectively inhibits the release of IL-1β and IL-18, with IC50 values of 1.9 uM and 1.0 uM, respectively, in human PBMC-derived macrophage model.
A13 exhibits modest GSTO1 engagement in both cell-free and cellular CMFDA assays.
A13 inhibits NLRP3 inflammasome–associated IL-1β and IL-18 release in both mouse bone marrow-derived macrophages and human monocyte-derived macrophages.
Physicochemical Properties
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M.Wt
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353.36
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Formula
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C16H14F3N3OS
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-1-(2-(5-(4-(Trifluoromethyl)phenyl)-1,3,4-thiadiazol-2-yl)pyrrolidin-1-yl)prop-2-en-1-one
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References
1. Yanli Sun, et al. J Med Chem. 2025 Nov 13. doi: 10.1021/acs.jmedchem.5c01724.
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