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Chemical Structure : GV-58
CAS No.: 1402821-41-3
Catalog No.: PC-43065Not For Human Use, Lab Use Only.
GV-58 is a potent, selective N-Type and P/Q-type Ca2+ Channel agonist with EC50 of 7.2 and 8.8 uM, shows no acitivity for L-type calcium channels (EC50>100 uM).
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|---|---|---|---|
| 5 mg | $240 | In stock | |
| 25 mg | $580 | In stock | |
| 100 mg | Get quote | ||
| 250 mg | Get quote |
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GV-58 is a potent, selective N-Type and P/Q-type Ca2+ Channel agonist with EC50 of 7.2 and 8.8 uM, shows no acitivity for L-type calcium channels (EC50>100 uM); has 20-fold less potent cyclin-dependent kinase antagonist effect; slows deactivation (closing) of the channel, resulting in a large increase in total calcium entry during motor nerve action potential activity; weakens Lambert-Eaton myasthenic syndrome-model neuromuscular synapses in a passive transfer mouse model of Lambert-Eaton myasthenic syndrome.
| M.Wt | 374.5036 | |
| Formula | C18H26N6OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-Butanol, 2-[[6-[[(5-methyl-2-thienyl)methyl]amino]-9-propyl-9H-purin-2-yl]amino]-, (2R)- |
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1. Tarr TB, et al. Ann N Y Acad Sci. 2012 Dec;1275:85-91.
2. Tarr TB, et al. J Neurosci. 2013 Jun 19;33(25):10559-67.
3. Tarr TB, et al. J Physiol. 2014 Aug 15;592(16):3687-96.
4. Liang M, et al. ACS Med Chem Lett. 2012 Oct 1;3(12):985-90.
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