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Chemical Structure : GW-6604
CAS No.: 452342-37-9
Catalog No.: PC-70053Not For Human Use, Lab Use Only.
GW-6604 (GW6604) is a TGF-beta signaling pathway inhibitor that tagets ALK5, inhibits autophosphorylation of ALK5 with an IC50 of 140 nM in vitro and inhibits TGF-beta-induced transcription of PAI-1 (IC50=500 nM) in a cellular assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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GW-6604 (GW6604) is a TGF-beta signaling pathway inhibitor that tagets ALK5, inhibits autophosphorylation of ALK5 with an IC50 of 140 nM in vitro and inhibits TGF-beta-induced transcription of PAI-1 (IC50=500 nM) in a cellular assay.
GW-6604 increases liver regeneration in TGF-beta-overexpressing mice at 40 mg kg(-1) p.o.
| M.Wt | 298.34 | |
| Formula | C19H14N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Phenyl-4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]pyridine |
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1. de Gouville AC, et al. Br J Pharmacol. 2005 May;145(2):166-77.
2. de Gouville AC, et al. Drug News Perspect. 2006 Mar;19(2):85-90.
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