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Chemical Structure : GW2580
CAS No.: 870483-87-7
Catalog No.: PC-42737Not For Human Use, Lab Use Only.
A potent, selective c-Fms (CSF1R) inhibitor that completely inhibits human cFMS kinase in vitro at 60 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $60 | In stock | |
| 100 mg | $74.4 | In stock | |
| 200 mg | $112 | In stock | |
| 500 mg | Get quote |
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A potent, selective c-Fms (CSF1R) inhibitor that completely inhibits human cFMS kinase in vitro at 60 nM; 150- to 500-fold selective compared to 26 other kinases (cKIT, cSRC, EGFR, etc.); completely inhibits the growth of CSF-1-dependent mouse myeloid M-NFS-60 cells at 0.7 uM; inhibits LPS-induced TNF production in mice and orally bioavailable.
| M.Wt | 366.4137 | |
| Formula | C20H22N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 17.5 mg/mL |
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| Chemical Name/SMILES |
2,4-Pyrimidinediamine, 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]- |
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1. Conway JG, et al. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16078-83.
2. Conway JG, et al. J Pharmacol Exp Ther. 2008 Jul;326(1):41-50.
3. Priceman SJ, et al. Blood. 2010 Feb 18;115(7):1461-71.
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