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Chemical Structure : GW405833 hydrochloride
CAS No.: 1202865-22-2
Catalog No.: PC-60728Not For Human Use, Lab Use Only.
GW405833 is a potent, selective cannabinoid receptor CB2 agonist with Ki of 3.6 nM, 1200-fold selectivity over CB1.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GW405833 is a potent, selective cannabinoid receptor CB2 agonist with Ki of 3.6 nM, 1200-fold selectivity over CB1.
GW405833 causes a concentration-dependent inhibition of forskolin-mediated cAMP accumulation in CHO-K1 cells with EC50 of 0.65 nM.
GW405833 elicits potent and efficacious antihyperalgesic effects in rodent models of neuropathic, incisional and chronic inflammatory pain.
| M.Wt | 483.814 | |
| Formula | C23H25Cl3N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(2,3-dichloro-phenyl)-[5-methoxy-2-methyl-3-(2-morpholin-4-yl-ethyl)-indol-1-yl]-methanone hydrochloride |
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1. Valenzano KJ, et al. Neuropharmacology. 2005 Apr;48(5):658-72.
2. Whiteside GT, et al. Eur J Pharmacol. 2005 Dec 28;528(1-3):65-72.
3. Hu B, et al. Pain. 2009 Jun;143(3):206-12.
4. Li AL, et al. J Pharmacol Exp Ther. 2017 Aug;362(2):296-305.
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