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Chemical Structure : GW440139B
Catalog No.: PC-72529Not For Human Use, Lab Use Only.
GW440139B is a potent RIPK3 inhibitor, suppresses necroptosis driven by dimerizable RIPK3 with IC50 of 73.6 nM.
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GW440139B is a potent RIPK3 inhibitor, suppresses necroptosis driven by dimerizable RIPK3 with IC50 of 73.6 nM.
GW440139B inhibits TNF- and TRIF-mediated necroptosis independent of RIPK1-RIPK3 interaction, directly inhibited RIPK3-mediated MLKL phosphorylation at Ser345, thus inhibiting necroptosis.
| M.Wt | 327.387 | |
| Formula | C21H17N3O | |
| Appearance | Solid | |
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1. D A Rodriguez, et al. Cell Death Differ. 2016 Jan;23(1):76-88.
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