GW440139B | RIPK3 inhibitor | Probechem Biochemicals

Chemical Structure : GW440139B

GW440139B (GW 440139B)

Catalog No.: PC-72529Not For Human Use, Lab Use Only.

GW440139B is a potent RIPK3 inhibitor, suppresses necroptosis driven by dimerizable RIPK3 with IC50 of 73.6 nM.

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Biological Activity

GW440139B is a potent RIPK3 inhibitor, suppresses necroptosis driven by dimerizable RIPK3 with IC50 of 73.6 nM.
GW440139B inhibits TNF- and TRIF-mediated necroptosis independent of RIPK1-RIPK3 interaction, directly inhibited RIPK3-mediated MLKL phosphorylation at Ser345, thus inhibiting necroptosis.

Physicochemical Properties

M.Wt	327.387
Formula	C21H17N3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-methyl-3-((7-(pyridin-2-yl)quinolin-4-yl)amino)phenol

References

1. D A Rodriguez, et al. Cell Death Differ. 2016 Jan;23(1):76-88.

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GW440139B (GW 440139B)

Biological Activity

Physicochemical Properties

References

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