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Chemical Structure : GW 5074
CAS No.: 220904-83-6
Catalog No.: PC-42645Not For Human Use, Lab Use Only.
GW 5074 is a potent, selective c-Raf inhibitor with IC50 of 9 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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GW 5074 is a potent, selective c-Raf inhibitor with IC50 of 9 nM.
GW 5074 shows >1000-fold selectivity for raf kinase versus CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2, and c-Fms.
| M.Wt | 520.942 | |
| Formula | C15H8Br2INO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2H-Indol-2-one, 3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo- |
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1. Lackey K, et al. Bioorg Med Chem Lett. 2000 Feb 7;10(3):223-6.
2. Yue X, et al. Eur J Pharmacol. 2006 Jul 1;540(1-3):57-9.
3. Jensen HA, et al. Cell Signal. 2015 Aug;27(8):1666-75.
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