Catalog No.: PC-38471Not For Human Use, Lab Use Only.
GW779439X is a small-molecule kinase inhibitor that sensitizes methicillin-resistant Staphylococcus aureus (MRSA) to β-lactam antibiotics via inhibition of the PASTA kinase Stk1.
GW779439X is a small-molecule kinase inhibitor that sensitizes methicillin-resistant Staphylococcus aureus (MRSA) to β-lactam antibiotics via inhibition of the PASTA kinase Stk1.
GW779439X potentiates β-lactam activity against multiple MRSA and MSSA isolates, including the sensitization of a ceftaroline-resistant isolate to ceftaroline.
GW779439X potentiates β-lactam activity via direct inhibition of Stk1.
GW779439X also interacts in the active site of the Aurora-a kinase (AURKA) enzyme.
GW779439X was originally designed for human CDK4 but failed to progress clinically because of high toxicity and low specificity.
The penicillin-binding-protein and serine/threonine kinase-associated (PASTA) kinases has attracted attention as targets for antibiotic adjuvants for β-lactams.
