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Chemical Structure : GW788388
CAS No.: 452342-67-5
Catalog No.: PC-42525Not For Human Use, Lab Use Only.
GW788388 is a potent, selective, and orally active TGF-β type I receptor (ALK5) inhibitor with IC50 of 18 nM in binding assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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GW788388 is a potent, selective, and orally active TGF-β type I receptor (ALK5) inhibitor with IC50 of 18 nM in binding assay.
GW788388 displays excellent selectivity over a panel of kinases (AMPK, Chk1, PDK1, etc.).
GW788388 has an IC50 of 93 nM in TGF-β cellular assay.
GW788388 presents activity in a PAN-induced model of kidney fibrosis by inhibiting collagen IA1 mRNA at doses of 3 and 10 mg/kg u.i.d.
| M.Wt | 425.4824 | |
| Formula | C25H23N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 48 mg/mL |
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| Chemical Name/SMILES |
Benzamide, 4-[4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-2-pyridinyl]-N-(tetrahydro-2H-pyran-4-yl)- |
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1. Gellibert F, et al. J Med Chem. 2006 Apr 6;49(7):2210-21.
2. Petersen M, et al. Kidney Int. 2008 Mar;73(6):705-15.
3. de Oliveira FL, et al. PLoS Negl Trop Dis. 2012;6(6):e1696.
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