GW791343 | P2X7 antagonist | Probechem Biochemicals

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Chemical Structure : GW791343

GW791343 (GW791343 dihydrochloride)

Catalog No.: PC-25894Not For Human Use, Lab Use Only.

GW791343 dihydrochloride is a selective, allosteric antagonist with negative allosteric effects at the human P2X7 receptor with pIC50 of 6.9-7.2, but is a positive allosteric modulator of the rat P2X(7) receptor.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	447.35
Formula	C20H26Cl2F2N4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((3,4-Difluorophenyl)amino)-N-(2-methyl-5-(piperazin-1-ylmethyl)phenyl)acetamide dihydrochloride

References

1. Michel AD, et al. Br J Pharmacol. 2008 Feb;153(4):737-50.

2. Michel AD, et al. Br J Pharmacol. 2008 Nov;155(5):738-51.

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GW791343 (GW791343 dihydrochloride)

Biological Activity

Physicochemical Properties

References

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