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GW869516X

Chemical Structure : GW869516X

CAS No.: 774461-45-9

GW869516X (GW-869516X)

Catalog No.: PC-26111Not For Human Use, Lab Use Only.

GW869516X is a highly potent casein kinase 2 (CK2) inhibitor with IC50 of 85 nM and 34 nM for CSNK2A1 (CK2α) and CSNK2A2 (CK2α') in recombinant kinase assays, and IC50 of 446 and 319 nM in NanoBRET assays.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

GW869516X is a highly potent casein kinase 2 (CK2) inhibitor with IC50 of 85 nM and 34 nM for CSNK2A1 (CK2α) and CSNK2A2 (CK2α') in recombinant kinase assays, and IC50 of 446 and 319 nM in NanoBRET assays.

Physicochemical Properties

M.Wt 430.47
Formula C23H22N6O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

7-(1H-indol-2-yl)-5-methyl-N-(3,4,5-trimethoxyphenyl)imidazo[5,1-f][1,2,4]triazin-2-amine

References

1. Maria Reinecke, et al. Nat Chem Biol. 2024 May;20(5):577-585.

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