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Chemical Structure : GYS32661
Catalog No.: PC-20183Not For Human Use, Lab Use Only.
GYS32661 (GYS 32661) is a potent Rac inhibitor capable of inhibiting both Rac1 and Rac1b, inhibited activated Rac1 with IC50 of 1.18 uM in in vitro pull-down assays.
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GYS32661 (GYS 32661) is a potent Rac inhibitor capable of inhibiting both Rac1 and Rac1b, inhibited activated Rac1 with IC50 of 1.18 uM in in vitro pull-down assays.
GYS32661 showed significant inhibition of Rac1 and Rac1b activity at 5 μmol/L in HCT116 colorectal cancer cells.
GYS32661 (10 uM) significantly blocked Rac1b-mediated NF-κB activity, attenuated TNFα-stimulated NF-κB activity.
GYS32661 attenuated phosphorylation of both IKBα and RelA/p65, inhibited downstream activation of NF-κB signaling in colorectal cancer. GYS32661sensitized colorectal cancer cells to chemotherapy (Oxaliplatin).
GYS32661 was shown to have higher activity against both recombinant Rac1 and recombinant Rac1b than EHT1864.
GYS32661 reduced the growth rates in xenograft models of human CRC in mice.
| M.Wt | 464.55 | |
| Formula | C23H27F3N4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Erik T Goka, et al. Mol Cancer Ther. 2019 May;18(5):957-968.
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