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Chemical Structure : Gamitrinib TPP hexafluorophosphate
CAS No.: 1131626-47-5
Catalog No.: PC-38121Not For Human Use, Lab Use Only.
Gamitrinib is a small molecule mitochondrial Hsp90 inhibitor, selectively targets Hsp90 network in tumor mitochondria.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $268 | In stock | |
| 5 mg | $758 | In stock | |
| 10 mg | $1280 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Gamitrinib is a small molecule mitochondrial Hsp90 inhibitor, selectively targets Hsp90 network in tumor mitochondria.
Gamitrinibs were shown to accumulate in the mitochondria of human tumor cell lines and to inhibit Hsp90 activity by acting as ATPase antagonists.
Unlike Hsp90 antagonists not targeted to mitochondria, Gamitrinibs exhibited a "mitochondriotoxic" mechanism of action, causing rapid tumor cell death and inhibiting the growth of xenografted human tumor cell lines in mice.
Gamitrinib is not toxic to normal cells or tissues and did not affect Hsp90 homeostasis in cellular compartments other than mitochondria.
| M.Wt | 1036.04 | |
| Formula | C52H65F6N3O8P2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(6-(((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-9-(carbamoyloxy)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-19-yl)amino)hexyl)triphenylphosphonium hexafluorophosphate(V) |
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1. Wei S, et al. Clin Cancer Res. 2022 Mar 4:clincanres.0833.2021.
2. Kang BH, et al. J Clin Invest. 2009 Mar;119(3):454-64.
3. Kang BH, et al. Br J Cancer. 2011 Feb 15;104(4):629-34.
4. Park HK, et al. Mol Cancer. 2014 Jun 12;13:148.
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