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Chemical Structure : Garsorasib
CAS No.: 2559761-14-5
Catalog No.: PC-73419Not For Human Use, Lab Use Only.
Garsorasib (D-1553) is a potent, selective, orally bioavailable and covalent KRas-G12C inhibitor with IC50 of 10 nM, exhibits potent anti-tumor activity in a broad spectrum of tumor cell lines.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $388 | In stock | |
| 10 mg | $588 | In stock | |
| 25 mg | $898 | In stock | |
| 100 mg | Get quote | ||
| 1 g | Get quote |
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Garsorasib (D-1553) is a potent, selective, orally bioavailable and covalent KRas-G12C inhibitor with IC50 of 10 nM, exhibits potent anti-tumor activity in a broad spectrum of tumor cell lines.
Garsorasib (D-1553) shows specific activity in cancer cells with KRas-G12C mutation, including lung, pancreatic and colorectal cancers.
Garsorasib (D-1553) is highly potent in vivo in various cell line-derived xenograft tumor models with KRas-G12C mutation as a single agent.
Garsorasib (D-1553) demonstrates further tumor growth inhibition or regression in tumor xenograft models, when combined with MEK inhibitor, SHP2 inhibitor or cytotoxic agents.
Garsorasib (D-1553) has anti-tumor activity in a broad spectrum of cancers and is suitable for tissue-agnostic clinical development targeting cancers with KRas-G12C mutation.
| M.Wt | 598.659 | |
| Formula | C32H32F2N8O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
7-(2-amino-6-fluorophenyl)-1-(4,6- dicyclopropylpyrimidin-5-yl)-4-[(2S,5R)-2,5-dimethyl-4- (prop-2-enoyl)piperazin-1-yl]-6-fluoropyrido[2,3- d]pyrimidin-2(1H)-one |
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1. Albert K Kwan, et al. J Exp Clin Cancer Res. 2022 Jan 19;41(1):27.
2. Zhe Shi, et al. Cancer Res (2021) 81 (13_Supplement): 932.
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