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GeA-69

Chemical Structure : GeA-69

CAS No.: 2143475-98-1

GeA-69 (GeA69)

Catalog No.: PC-60021Not For Human Use, Lab Use Only.

GeA-69 (GeA69) is a potent, selective, allosteric, cell-active PARP14 macrodomain 2 (MD2) inhibitor with Kd of 0.86 uM in ITC assays.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

GeA-69 (GeA69) is a potent, selective, allosteric, cell-active PARP14 macrodomain 2 (MD2) inhibitor with Kd of 0.86 uM in ITC assays; displays high selectivity over other human macrodomains; engages PARP14 MD2 in intact cells and prevents its localization to sites of DNA damage.

Physicochemical Properties

M.Wt 300.361
Formula C20H16N2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(2-(9H-carbazol-1-yl)phenyl)acetamide

References

1. Schuller M, et al. ACS Chem Biol. 2017 Nov 17;12(11):2866-2874.

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