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Chemical Structure : Gedatolisib
CAS No.: 1197160-78-3
Catalog No.: PC-60057Not For Human Use, Lab Use Only.
Gedatolisib (PF-05212384, PKI-587) is a highly potent, selective, dual PI3K/mTOR inhibitor with IC50 of 0.4/6/8/6/1.6 nM for PI3Kα/β/γ/δ/mTOR, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Gedatolisib (PF-05212384, PKI-587) is a highly potent, selective, dual PI3K/mTOR inhibitor with IC50 of 0.4/6/8/6/1.6 nM for PI3Kα/β/γ/δ/mTOR, respectively.
PF-05212384 also potently inhibits PI3Kα mutant H1047R and E545K with IC50 of 0.6 and 0.6 nM.
PF-05212384 prevents the pAkt at Thr 308 with IC50 of 8 nM, and suppresses pAkt S473 with IC50 of <10 nM in cells.
PF-05212384 demonstrates antitumor efficacy in both subcutaneous and orthotopic xenograft tumor models.
| M.Wt | 615.72 | |
| Formula | C32H41N9O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(4-{[4-(Dimethylamino)-1-piperidinyl]carbonyl}phenyl)-3-{4-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]phenyl}urea |
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1. Venkatesan AM, et al. J Med Chem. 2010 Mar 25;53(6):2636-45.
2. Mallon R, et al. Clin Cancer Res. 2011 May 15;17(10):3193-203.
3. Gedaly R, et al. J Surg Res. 2013 Nov;185(1):225-30.
4. D'Amato V, et al. Br J Cancer. 2014 Jun 10;110(12):2887-95.
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