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Gemigliptin tartrate

Chemical Structure : Gemigliptin tartrate

CAS No.: 1374639-74-3

Gemigliptin tartrate (LC15-0444)

Catalog No.: PC-27467Not For Human Use, Lab Use Only.

Gemigliptin tartrate (LC15-0444) is a potent, selective, competitive and orally active DPP4 inhibitor (IC50=10.4 nM, hDPP4) with potential for the treatment of type 2 diabetes.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Gemigliptin tartrate (LC15-0444) is a potent, selective, competitive and orally active DPP4 inhibitor (IC50=10.4 nM, hDPP4) with potential for the treatment of type 2 diabetes.
Gemigliptin exhibits potent anti-glycation properties in vitro and in vivo, also improves renal function and attenuates podocyte injury in mice with diabetic nephropathy.

Physicochemical Properties

M.Wt 639.46
Formula C22H25F8N5O8
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-1-(2-amino-4-(2,4-bis(trifluoromethyl)-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl)-4-oxobutyl)-5,5-difluoropiperidin-2-one tartrate

References

1. Lim KS, et al. Br J Clin Pharmacol. 2009 Dec;68(6):883-90.

2. Hwang HJ, et al. Mol Cell Endocrinol. 2014 Jul 5;392(1-2):1-7.

3. Jung E, et al. Eur J Pharmacol. 2014 Dec 5;744:98-102.

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