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Chemical Structure : Genz-667348
Catalog No.: PC-20266Not For Human Use, Lab Use Only.
Genz-667348 (Genz667348) is a potent, selective P. falciparum DHODH inhibitor with IC50 of 22, 14 and 42 nM for PfDHODH, PbDHODH and PvDHODH, respectively.
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Genz-667348 (Genz667348) is a potent, selective P. falciparum DHODH inhibitor with IC50 of 22, 14 and 42 nM for PfDHODH, PbDHODH and PvDHODH, respectively.
Genz-667348 demonstrates in vitro potency against the 3D7 and Dd2 strains of P. falciparum with IC50 of 7 and 10 nM, respectively.
Genz-667348 (ED50=21.0 mg/kg/day) demonstrates in vivo efficacy in the P. berghei mouse model.
| M.Wt | 381.37 | |
| Formula | C17H14F3N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Michael L Booker, et al. J Biol Chem. 2010 Oct 22;285(43):33054-33064.
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