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Chemical Structure : Ghrelin agonist HM01
Catalog No.: PC-35623Not For Human Use, Lab Use Only.
Ghrelin agonist HM01 is a novel potent, orally available ghrelin (GHS-R) agonist with Ki of 1.42 nM (human GHS-R1a), induces potent activation of intracellular calcium signaling with EC50 of 1.25 nM.
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Ghrelin agonist HM01 is a novel potent, orally available ghrelin (GHS-R) agonist with Ki of 1.42 nM (human GHS-R1a), induces potent activation of intracellular calcium signaling with EC50 of 1.25 nM; mimics the neuronal effects of ghrelin in the arcuate nucleus and attenuates anorexia-cachexia syndrome in tumor-bearing rats, also attenuates cachexia in mice bearing bolon-26 (C26) tumors.
| M.Wt | 402.36 | |
| Formula | C19H29Cl2N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rudd JA, et al. Front Pharmacol. 2018 Aug 6;9:869.
2. Karasawa H, et al. Neurogastroenterol Motil. 2014 Dec;26(12):1771-82.
3. Villars FO, et al. Int J Mol Sci. 2017 May 5;18(5). pii: E986.
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