Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Gilteritinib
CAS No.: 1254053-43-4
Catalog No.: PC-43033Not For Human Use, Lab Use Only.
Gilteritinib (ASP2215) is a potent FLT3/AXL inhibitor with IC50 of 0.73 nM/0.29 nM respectively; also inhibits LTK and ALK (IC50=0.35 nM and 1.2 nM respectively).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | $528 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Gilteritinib (ASP2215) is a potent FLT3/AXL inhibitor with IC50 of 0.73 nM/0.29 nM respectively; also inhibits LTK and ALK (IC50=0.35 nM and 1.2 nM respectively).
Gilteritinib (ASP2215) shows >800-fold selectivity over c-Kit.
Gilteritinib (ASP2215) inhibits the growth of Ba/F3 cells expressing either FLT3-ITD, FLT3-D835Y, FLT3-ITD-D835Y, FLT3-ITD-F691 L, and FLT3-ITD-F691I, with IC50 of 1.8 nM, 1.6 nM, 2.1 nM, 22 nM, and 49 nM, respectively.
Gilteritinib (ASP2215) is orally bioactive.
| M.Wt | 552.7115 | |
| Formula | C29H44N8O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
DMSO |
|
| Chemical Name/SMILES |
2-Pyrazinecarboxamide, 6-ethyl-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[(tetrahydro-2H-pyran-4-yl)amino]- |
|
1. Mori M, et al. Invest New Drugs. 2017 May 17. doi: 10.1007/s10637-017-0470-z.
2. Lee LY, et al. Blood. 2017 Jan 12;129(2):257-260.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
