Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Givinostat hydrochloride monohydrate
CAS No.: 732302-99-7
Catalog No.: PC-20913Not For Human Use, Lab Use Only.
Givinostat (ITF-2357) is a potent, orally active, pan-HDAC inhibitor with IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $498 | In stock | |
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Givinostat (ITF-2357) is a potent, orally active, pan-HDAC inhibitor with IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively.
Givinostat (ITF-2357) has anti-leukemic activity in vitro and in vivo and inhibits IL-6 and VEGF production by stromal cells.
Givinostat (ITF-2357) reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo.
Givinostat (ITF-2357) reduces cytokines and protects islet β cells in vivo and in vitro.
| M.Wt | 475.97 | |
| Formula | C24H30ClN3O5 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
O=C(OCC1=CC=C2C=C(CN(CC)CC)C=CC2=C1)NC3=CC=C(C(NO)=O)C=C3.[H]Cl.[H]O[H] |
|
1. Li S, et al. J Biol Chem. 2015 Jan 23;290(4):2368-78.
2. Leoni F, et al. Mol Med. 2005 Jan-Dec;11(1-12):1-15.
3. Golay J, et al. Leukemia. 2007 Sep;21(9):1892-900.
4. Guerini V, et al. Leukemia. 2008 Apr;22(4):740-7.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
