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Chemical Structure : Glabrescione B
Catalog No.: PC-63516Not For Human Use, Lab Use Only.
Glabrescione B (GlaB) is a small molecule binding to Gli1 zinc finger and impairing Gli1 activity by interfering with Gli1/DNA interaction, inhibits Hh signaling by impairing Gli1 function.
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Glabrescione B (GlaB) is a small molecule binding to Gli1 zinc finger and impairing Gli1 activity by interfering with Gli1/DNA interaction, inhibits Hh signaling by impairing Gli1 function; inhibits the growth of Hedgehog-dependent tumor cells in vitro and in vivo, inhibits Gli1-dependent growth of cerebellum-derived normal progenitors; inhibits the growth of Gli-dependent medulloblastoma and tumor-derived stem-like cells; inhibits the growth of Gli-dependent basal cell carcinoma in vitro and in vivo.
| M.Wt | 450.531 | |
| Formula | C27H30O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Infante P, et al. EMBO J. 2015 Jan 13;34(2):200-17.
2. Ingallina C, et al. Nanomedicine (Lond). 2017 Apr;12(7):711-728.
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