Grp78 inhibitor 8

Chemical Structure : Grp78 inhibitor 8

CAS No.: 2707510-30-1

Catalog No.: PC-49601Not For Human Use, Lab Use Only.

Grp78 inhibitor 8 is a potent, isoform-selective inhibitor of the ER Resident Chaperone Grp78 (HSPA5) with IC50 of 0.59 uM.

Packing	Price	Stock
5 mg	$118	In stock
10 mg	$188	In stock
25 mg	$328	In stock
50 mg	$548	In stock
100 mg		Get quote

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Biological Activity

Grp78 inhibitor 8 is a potent, isoform-selective inhibitor of the ER Resident Chaperone Grp78 (HSPA5) with IC50 of 0.59 uM.
Grp78 inhibitor 8 is 7-fold selective for HspA5 over HspA9 (IC50 of 4.3 μM) and >20-fold selective for HspA5 compared to HspA2 (IC50 of 13.9 μM).

Physicochemical Properties

M.Wt	342.42
Formula	C17H18N4O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(3-methyl-1-oxo-1-(thiazol-2-ylamino)butan-2-yl)-1H-indole-2-carboxamide

References

1. Ambrose AJ,et al. J Med Chem. 2022 Dec 14. doi: 10.1021/acs.jmedchem.2c01631.

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