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Chemical Structure : GsMTx4
CAS No.: 1209500-46-8
Catalog No.: PC-20552Not For Human Use, Lab Use Only.
GsMTx4 is a spider venom peptide that selectively inhibits cationic mechanosensitive channels (MSCs) such as TRPC1 and TRPC6 and Piezo channels, also blocks cation-selective stretch-activated channels (SACs).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 500 ug | $298 | In stock | |
| 1 mg | $448 | In stock | |
| 5 mg | $798 | In stock | |
| 10 mg | Get quote | ||
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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GsMTx4 is a spider venom peptide that selectively inhibits cationic mechanosensitive channels (MSCs) such as TRPC1 and TRPC6 and Piezo channels, also blocks cation-selective stretch-activated channels (SACs).
GsMTx4 attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity.
GsMTx4 (5 μM) reduces Piezo1-mediated charge transfer to 38% of its initial levels in HEK293 cells transfected with Piezo1 cDNA.
GsMTx4 (5 μM) blocks cation-selective stretch-activated channels in astrocytes, cardiac cells, and smooth and skeletal muscle cells.
GsMTx4 also inhibits TACAN, a mechanosensitive ion channel involved in the pain response.
GsMTx4 is neuroprotective and inhibits lysophosphatidylcholine-induced astrocyte toxicity in vivo in mice.
| M.Wt | 4095.86 | |
| Formula | C185H273N49O45S6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
[H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C) |
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1. Suchyna TM, et al. Nature. 2004 Jul 8;430(6996):235-40.
2. Suchyna TM, et al. J Gen Physiol. 2000 May;115(5):583-98.
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