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Chemical Structure : H2L5186303
CAS No.: 139262-76-3
Catalog No.: PC-49229Not For Human Use, Lab Use Only.
H2L5186303 is a potent, selective LPA2 receptor antagonist with IC50 of 8.9 nM, no significant activity against LPA1 and LPA3 receptors (IC50>1,000 nM), inhibits LPA(2) mediated Erk activation and proliferation of HCT-116 cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $358 | In stock | |
| 50 mg | $588 | In stock | |
| 100 mg | Get quote |
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H2L5186303 is a potent, selective LPA2 receptor antagonist with IC50 of 8.9 nM, no significant activity against LPA1 and LPA3 receptors (IC50>1,000 nM), inhibits LPA(2) mediated Erk activation and proliferation of HCT-116 cells.
| M.Wt | 488.452 | |
| Formula | C26H20N2O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-Butenoic acid, 4,4′-[1,3-phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-, (Z,Z)- |
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1. Hilary P Beck, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1037-41.
2. Chabowski DS, et al. Br J Pharmacol. 2018 Nov;175(22):4266-4280.
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