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Chemical Structure : HA-15
CAS No.: 1609402-14-3
Catalog No.: PC-42156Not For Human Use, Lab Use Only.
HA-15 is a specifc inhibitor of the chaperone BiP (Binding immunoglobulin protein, GRP78 or HSPA5) that displays anti-cancerous activity on melanoma cells, including BRAF resistance melanoma cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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HA-15 is a specifc inhibitor of the chaperone BiP (Binding immunoglobulin protein, GRP78 or HSPA5) that displays anti-cancerous activity on melanoma cells, including BRAF resistance melanoma cells.
HA-15 does not interact with IRE1α, ATF6, or HSP70, increases ER stress and induces autophagy and apoptosis.
HA-15 exhibits strong efficacy in xenograft mouse models with melanoma cells either sensitive or resistant to BRAF inhibitor.
| M.Wt | 466.5758 | |
| Formula | C23H22N4O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Acetamide, N-[4-[3-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-thiazolyl]- |
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1. Cerezo M, et al. Cancer Cell. 2016 Jun 13;29(6):805-819.
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