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Chemical Structure : HB007
Catalog No.: PC-72801Not For Human Use, Lab Use Only.
HB007 (HB-007) is a small-molecule degrader of the small ubiquitin-related modifier 1 (SUMO1) with anticancer potency in vitro and in vivo.
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HB007 (HB-007) is a small-molecule degrader of the small ubiquitin-related modifier 1 (SUMO1) with anticancer potency in vitro and in vivo.
HB007 selectively bound to cytoplasmic activation/proliferation-associated protein 1 (CAPRIN1), induced the interaction of CAPRIN1 with FBXO42, FBXO42 then recruited SUMO1 to the CAPRIN1-CUL1-FBXO42 ubiquitin ligase complex, where SUMO1 was ubiquitinated in several of human cancer cells.
HB007 selectively degraded SUMO1 in patient tumor-derived xenografts implanted into mice.
Systemic administration of HB007 inhibited the progression of patient-derived brain, breast, colon, and lung cancers in mice and increased survival of the animals.
| M.Wt | 328.78 | |
| Formula | C15H9ClN4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Anita C Bellail, et al. Sci Transl Med. 2021 Oct 13;13(615):eabh1486.
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