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Chemical Structure : HC-067047
CAS No.: 883031-03-6
Catalog No.: PC-42084Not For Human Use, Lab Use Only.
HC-067047 (HC067047) is a potent and selective TRPV4 antagonist with IC50 of 48 nM, 133 nM, and 17 nM for human, rat, and mouse TRPV4 in cell assays, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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HC-067047 (HC067047) is a potent and selective TRPV4 antagonist with IC50 of 48 nM, 133 nM, and 17 nM for human, rat, and mouse TRPV4 in cell assays, respectively.
HC067047 displays high selectivity against a variety of ion-channel targets, including representative channels of the TRPV, TRPC, TRPA, and TRPMs.
HC067047 inhibits endogenous TRPV4-mediated response to 4α-PDH with IC50 of 22 nM.
HC067047 increases functional bladder capacity and reduces micturition frequency in WT mice and rats with cystitis without effects on bladder function.
| M.Wt | 471.5146 | |
| Formula | C26H28F3N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1H-Pyrrole-3-carboxamide, 2-methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]- |
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1. Everaerts W, et al. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19084-9.
2. Jin M, et al. Cell Calcium. 2012 Feb;51(2):131-9.
3. Shahidullah M, et al. Am J Physiol Cell Physiol. 2012 Jun 15;302(12):C1751-61.
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