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Chemical Structure : HC-070
CAS No.: 1628291-95-1
Catalog No.: PC-62504Not For Human Use, Lab Use Only.
HC-070 is a potent, selective, orally active inhibitor of TRPC4 and TRPC5 channel with IC50 of 9.3 and 46 nM (calcium influx inhibition), respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $498 | In stock | |
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| 200 mg | Get quote | ||
| 1 g | Get quote |
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HC-070 is a potent, selective, orally active inhibitor of TRPC4 and TRPC5 channel with IC50 of 9.3 and 46 nM (calcium influx inhibition), respectively.
HC-070 displays >400-fold selectivity over a wide range of ion channels, receptors, and kinases.
HC-070 inhibits lanthanum-activated hTRPC5-mediated currents with an IC50 of 0.52 nM in whole-cell manual patch clamp assay, also inhibits TRPC1/5 and TRPC1/4 heteromultimers with similar potency and reduces responses evoked by cholecystokinin tetrapeptide (CCK-4) in the amygdala.
HC-070 attenuates the anxiogenic effect of CCK-4 in the elevated plus maze (EPM), and shows anxiolytic and anti-depressant effects in vivo.
| M.Wt | 475.326 | |
| Formula | C22H20Cl2N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
7-(4-chlorobenzyl)-8-(3-chlorophenoxy)-1-(3-hydroxypropyl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione |
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1. Just S, et al. PLoS One. 2018 Jan 31;13(1):e0191225.
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