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HDAC8 inhibitor Compound 4

Chemical Structure : HDAC8 inhibitor Compound 4

CAS No.: 932718-22-4

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HDAC8 inhibitor Compound 4

Catalog No.: PC-27747Not For Human Use, Lab Use Only.

HDAC8 inhibitor Compound 4 is a potent and selective HDAC8 inhibitor with IC50 of 90 nM, weakly inhibit HDAC1, HDAC2, HDAC6 with IC50 of 1.7 uM, 3.9 uM and >50 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

HDAC8 inhibitor Compound 4 is a potent and selective HDAC8 inhibitor with IC50 of 212 nM.

Physicochemical Properties

M.Wt 335.23
Formula C17H16Cl2N2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-2-amino-3-(2,4-dichlorophenyl)-1-(isoindolin-2-yl)propan-1-one

References

1. Lewis Whitehead, et al. Bioorg Med Chem. 2011 Aug 1;19(15):4626-34.

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