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Chemical Structure : HDACi-4b
CAS No.: 537034-15-4
Catalog No.: PC-42126Not For Human Use, Lab Use Only.
A benzamide-type HDAC inhibitor with IC50 of 78 uM for changes of FXN mRNA in affected GM15850 cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $328 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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HDACi-4b (NKL22) is a benzamide-type HDAC inhibitor with IC50 of 78 uM for changes of FXN mRNA in affected GM15850 cells.
HDACi-4b (NKL22) reverses FXN silencing in primary lymphocytes from individuals with Friedreich's ataxia.
HDACi-4b (NKL22) directly affects the histones associated with FXN, increasing acetylation at particular lysine residues on histones H3 and H4 (H3K14, H4K5 and H4K12).
HDACi-4b (NKL22) significantly improves motor performance, overall appearance, and body weight in an HD mouse model.
| M.Wt | 325.4048 | |
| Formula | C19H23N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 29 mg/mL |
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| Chemical Name/SMILES |
Heptanediamide, N1-(2-aminophenyl)-N7-phenyl- |
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1. Jia H, et al. Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):E56-64.
2. Thomas EA, et al. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15564-9.
3. Herman D, et al. Nat Chem Biol. 2006 Oct;2(10):551-8.
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