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HDM2004

Chemical Structure : HDM2004

CAS No.: 2953016-30-1

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HDM2004 (HDM-2004)

Catalog No.: PC-26106Not For Human Use, Lab Use Only.

HDM2004 is a potent, selective and orally bioavailable HPK1 (MAP4K1) inhibitor with IC50 of 1.89 nM, >30-fold selectivity over the closely related kinase GLK.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

HDM2004 is a potent, selective and orally bioavailable HPK1 (MAP4K1) inhibitor with IC50 of 1.89 nM, >30-fold selectivity over the closely related kinase GLK.
HDM2004 has IC50 of 38.9 nM on cytokine production in PBMC-IL-2 assays.
HDM2004 displays moderate kinome selectivity with potent "off target" kinase hits mainly include ROCK1, JAK3, JNK1, CLK1 and LCK, AXL and PKD2.
HDM2004 displayed synergistic antitumor activity when combined with PD-L1 blockade in syngeneic mouse models.

Physicochemical Properties

M.Wt 485.64
Formula C28H35N7O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2R,6R)-4-(4-(7-(1-(1-ethylpiperidin-4-yl)-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazin-2-yl)phenyl)-2,6-dimethylmorpholine

References

1. Zhimin Zhang, et al. Eur J Med Chem. 2026 Feb 20:308:118708.

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