Chemical Structure : HEC116094
CAS No.:
2200336-18-9
HEC116094
(HEC-116094)
Catalog No.: PC-27290Not For Human Use, Lab Use Only.
HEC116094 is a potent, specific inhibitor of influenza A virus polymerase PB2 subunit with IC50 of 0.337 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
HEC116094 is a potent, specific inhibitor of influenza A virus polymerase PB2 subunit with IC50 of 0.337 nM.
HEC116094 demonstrates potent activity against influenza A strains (H1N1 and H3N2), with IC50 values ranging from 0.012 to 0.069 nM, surpassing VX-787 and oseltamivir.
HEC116094 does not inhibit influenza B virus, and shows low cell cytotoxicity.
HEC116094 demonstrates IC50 values of 0.121 nM against H5N1 and 0.084 nM against H7N9 on MDCK cells.
HEC116094 (1, 3, or 10 mg/kg, BID, oral) is highly efficacious and safe in mouse influenza A virus infection model.
HEC116094 is strongly synergistic with oseltamivir in vitro.
Physicochemical Properties
|
M.Wt
|
482.51
|
|
Formula
|
C23H20F2N6O2S
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
(2S,3S)-3-((5-fluoro-2-(5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-yl)-6-(thiophen-2-yl)pyrimidin-4-yl)amino)bicyclo[2.2.2]octane-2-carboxylic acid
|
References
1. Longyu Nie, et al. Emerg Microbes Infect. 2026 Dec;15(1):2695531.
Contact Us
sales@probechem.com
