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Chemical Structure : HEC72702
Catalog No.: PC-63328Not For Human Use, Lab Use Only.
HEC72702 is a novel potent, orally active inhibitor of HBV capsid assembly, inhibits HBV-DNA levels in HepG.2.2.15 cells with IC50 of 39 nM.
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HEC72702 is a novel potent, orally active inhibitor of HBV capsid assembly, inhibits HBV-DNA levels in HepG.2.2.15 cells with IC50 of 39 nM; displays no induction of the CYP1A2, CYP3A4, or CYP2B6 enzyme at 10 uM, demonstrates a good systemic exposure and high oral bioavailability and achieves a viral-load reduction greater than 2 log in a hydrodynamic-injected (HDI) HBV mouse model.
| M.Wt | 581.457 | |
| Formula | C24H26BrFN4O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ren Q, et al. J Med Chem. 2018 Feb 8;61(3):1355-1374.
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