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Chemical Structure : HI-B1
CAS No.: 1458664-10-2
Catalog No.: PC-20582Not For Human Use, Lab Use Only.
HI-B1 is a small molecule inhibitor of β-catenin/TCF4 interaction, directly targets β-catenin and disrupts β-catenin/TCF4 complex formation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $278 | In stock | |
| 25 mg | $598 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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HI-B1 is a small molecule inhibitor of β-catenin/TCF4 interaction, directly targets β-catenin and disrupts β-catenin/TCF4 complex formation.
HI-B1 suppresses growth of several types of colon cancer cells (DLD1, CACO2 and HCT116), but did not affect the H838 lung cancer cell line, preferentially kills cancer cells in which β-catenin is critical for survival.
HI-B1 directly binds with β-catenin and disrupts the β-catenin/TCF4 interaction
HI-B1 (50 mg/kg, oral) inhibits β-catenin-driven tumorigenesis in PDX colon cancer models.
| M.Wt | 255.30 | |
| Formula | C15H14FN3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
CN(C)C1=CC=C(C2=NC3=CC(F)=CC=C3N2)C=C1 |
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1. Seung Ho Shin, et al. EBioMedicine. 2017 Nov;25:22-31.
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