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HIF1-IN-2

Chemical Structure : HIF1-IN-2

CAS No.: 159915-87-4

HIF1-IN-2

Catalog No.: PC-70269Not For Human Use, Lab Use Only.

A potent, selective HIF-1 inhibitor with IC50 of 1.9 nM, with no signigicant inhibition on HSF and NF-κB.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent, selective HIF-1 inhibitor with IC50 of 1.9 nM, with no signigicant inhibition on HSF and NF-κB; robustly induces PGK1 and Enolase 1 expression, also inhibit endogenous HIF-1 targets.

Physicochemical Properties

M.Wt 453.583
Formula C26H35N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(Z)-2-(2-((4-((E)-1-(butoxyimino)propyl)-2,5-dimethylphenoxy)methyl)phenyl)-2-(methoxyimino)-N-methylacetamide

References

1. Lin X, et al. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):174-9.

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