HIPK4 inhibitor 25

Chemical Structure : HIPK4 inhibitor 25

Catalog No.: PC-28455Not For Human Use, Lab Use Only.

HIPK4 inhibitor 25 is a selective HIPK4 inhibitor with IC50 of 0.54 uM in ADP-Glo assays and cellular HIPK4 engagement EC50 of 2.8 uM, promotes HIPK4-TAX1BP1 binding, efficiently promotes HIPK4 aggregation, disrupts HIPK4 proteostasis in spermatids.

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Biological Activity

HIPK4 inhibitor 25 is a selective HIPK4 inhibitor with IC50 of 0.54 uM in ADP-Glo assays and cellular HIPK4 engagement EC50 of 2.8 uM, promotes HIPK4-TAX1BP1 binding, efficiently promotes HIPK4 aggregation, disrupts HIPK4 proteostasis in spermatids.

Physicochemical Properties

M.Wt	339.78
Formula	C18H14ClN3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((4-Chlorophenyl)amino)-6,7-dimethoxyquinoline-3-carbonitrile

References

1. Zhuang Z, et al. J Am Chem Soc. 2026 Oct 5. doi: 10.1021/jacs.6c10097.

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