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Chemical Structure : HIV-1 Integrase inhibitor GS-B
Catalog No.: PC-72633Not For Human Use, Lab Use Only.
HIV-1 Integrase inhibitor GS-B (GS-B) is a novel non-catalytic site integrase inhibitor of HIV-1 integrase (IN), inhibits the interaction between LEDGF IBD and IN with IC50 of 8.1 nM.
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HIV-1 Integrase inhibitor GS-B (GS-B) is a novel non-catalytic site integrase inhibitor of HIV-1 integrase (IN), inhibits the interaction between LEDGF IBD and IN with IC50 of 8.1 nM.
GS-B displays antiviral potency in MT-4, MT-2, and human PBMCs with EC50 values of 18, 10, and 21 nM, respectively.
| M.Wt | 437.511 | |
| Formula | C26H28FNO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Manuel Tsiang, et al. J Biol Chem. 2012 Jun 15;287(25):21189-203.
2. Mini Balakrishnan, et al. PLoS One. 2013 Sep 9;8(9):e74163.
3. Yoshitsugu Ohata, et al. J Virol. 2022 Jan 19;JVI0184321.
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