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Chemical Structure : HIV-1 inhibitor 18A
Catalog No.: PC-62258Not For Human Use, Lab Use Only.
HIV-1 inhibitor 18A is a novel broad HIV-1 inhibitor that blocks envelope glycoprotein transitions critical for entry, specifically inhibits the entry of a wide range of HIV-1 isolates with mean IC50 of 6.4 uM.
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HIV-1 inhibitor 18A is a novel broad HIV-1 inhibitor that blocks envelope glycoprotein transitions critical for entry, specifically inhibits the entry of a wide range of HIV-1 isolates with mean IC50 of 6.4 uM; inhibits the CD4-induced disruption of quaternary structures at the trimer apex and the exposure of the gp41 HR1 coiled coil, does not interfere with CD4 or CCR5 binding.
| M.Wt | 313.33 | |
| Formula | C14H11N5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Herschhorn A, et al. Nat Chem Biol. 2014 Oct;10(10):845-52.
2. Berinyuy E, et al. J Recept Signal Transduct Res. 2016;36(2):119-29.
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