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Chemical Structure : HIV InSTI-1
Catalog No.: PC-60406Not For Human Use, Lab Use Only.
A potent HIV integrase strand transfer inhibitor (InSTIs) with IC50 of 8 nM in HIV replication assay.
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A potent HIV integrase strand transfer inhibitor (InSTIs) with IC50 of 8 nM in HIV replication assay; shows Mutant Fold Shift 1/1/1/1/2/4 for E92Q/Y143R/Q148R/Q148K/N155H/G140S-Q148H compared with WT enzyme, respectively; demonstrates desired virological profile and preclinical pharmacokinetic profile.
| M.Wt | 501.939 | |
| Formula | C25H25ClFN3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Schreier JD, et al. Bioorg Med Chem Lett. 2017 May 1;27(9):2038-2046.
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