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Chemical Structure : HJC0152
CAS No.: 1420290-99-8
Catalog No.: PC-60934Not For Human Use, Lab Use Only.
HJC0152 is a potent, orally bioavailable STAT3 signaling inhibitor that exhibits promising antitumor effects in vitro and in vivo via inactivating STAT3 and downstream miR-21/β-catenin axis.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | $528 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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HJC0152 is a potent, orally bioavailable STAT3 signaling inhibitor that exhibits promising antitumor effects in vitro and in vivo via inactivating STAT3 and downstream miR-21/β-catenin axis.
HJC0152 potently inhibits MCF-7, MDA-MB-231, AsPC1 and Panc-1a cell with IC50 of 0.91, 1.64, 1.9 and 1.08 uM, respectively.
HJC0152 suppresses HNSCC cell proliferation, arrests the cell cycle at the G0-G1 phase, induces apoptosis and reduces cell invasion in both SCC25 and CAL27 cell lines.
HJC0152 inhibits nuclear translocation of phosphorylated STAT3 at Tyr705 and decreases VHL/β-catenin signaling activity via regulation of miR-21。
HJC0152 suppresses MDA-MB-231 xenograft tumor growth in vivo.
| M.Wt | 406.644 | |
| Formula | C15H14Cl3N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-(2-aminoethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide hydrochloride |
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1. Chen H, et al. ACS Med Chem Lett. 2013 Feb 14;4(2):180-185.
2. Wang Y, et al. Mol Cancer Ther. 2017 Apr;16(4):578-590.
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