Chemical Structure : HM2-16F
CAS No.:
2387931-69-1
HM2-16F
Catalog No.: PC-28618Not For Human Use, Lab Use Only.
HM2-16F is an anti-tubercular inhibitor with bactericidal properties that inhibiting cytochrome bd oxidase (Cyt-bd), inhibits the growth of bedaquiline-resistant mutants, weakly inhibits F1Fo-ATP synthase, depletes ATP, and affects the entry of acetyl-CoA into the Krebs cycle, synergizes with the cytochrome bcc-aa3 oxidase inhibitor Q203 (Telacebec).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
HM2-16F is an anti-tubercular inhibitor with bactericidal properties that inhibiting cytochrome bd oxidase (Cyt-bd), inhibits the growth of bedaquiline-resistant mutants, weakly inhibits F1Fo-ATP synthase, depletes ATP, and affects the entry of acetyl-CoA into the Krebs cycle, synergizes with the cytochrome bcc-aa3 oxidase inhibitor Q203 (Telacebec).
Physicochemical Properties
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M.Wt
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311.31
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Formula
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C14H13N7O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3,5-diamino-6-(benzofuran-2-yl)-N-carbamimidoylpyrazine-2-carboxamide
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References
1. Islam MI, et al. J Bacteriol. 2021 Oct 25;203(22):e0036721.
2. Hards K, et al. Commun Biol. 2022 Feb 24;5(1):166.
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