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Chemical Structure : HMN-214
CAS No.: 173529-46-9
Catalog No.: PC-42860Not For Human Use, Lab Use Only.
HMN-214 (IVX 214, TV-7101) is a prodrug of HMN-176 for oral administration, HMN-176 is a stilbene derivative that interferes with the subcellular spatial location of PLK1, does not inhibit PLK directly.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | Get quote |
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HMN-214 (IVX 214, TV-7101) is a prodrug of HMN-176 for oral administration, HMN-176 is a stilbene derivative that interferes with the subcellular spatial location of PLK1, does not inhibit PLK directly.
HMN-214 suppresses the expression of MDR1 mRNA in mouse xenograft model implanted with KB-A.1, an Adriamycin-resistant cell line.
HMN-176 inhibits the Y-box-dependent promoter activity of the MDR1 gene in a dose-dependent manner.
| M.Wt | 424.4696 | |
| Formula | C22H20N2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Acetamide, N-[(4-methoxyphenyl)sulfonyl]-N-[2-[(1E)-2-(1-oxido-4-pyridinyl)ethenyl]phenyl]- |
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1. Tanaka H, et al. Cancer Res. 2003 Oct 15;63(20):6942-7.
2. Takagi M, et al. Invest New Drugs. 2003 Nov;21(4):387-99.
3. Garland LL, et al. Clin Cancer Res. 2006 Sep 1;12(17):5182-9.
4. Christensen MD, et al. J Control Release. 2015 Apr 28;204:20-9.
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