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Chemical Structure : HO53
Catalog No.: PC-20239Not For Human Use, Lab Use Only.
HO53 is a small moecule inducer of cathelicidin antimicrobial peptide gene (CAMP) expression in bronchial epithelium cells, HO53 is a histone deacetylase (HDAC) inhibitor, interacts directly with HDAC3.
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HO53 is a small moecule inducer of cathelicidin antimicrobial peptide gene (CAMP) expression in bronchial epithelium cells, HO53 is a histone deacetylase (HDAC) inhibitor, interacts directly with HDAC3.
HO53 treatment affects expression of multiple genes and leads to Histone 3 acetylation on undifferentiated BCi cells.
HO53 induces CAMP gene expression through modulation of HAT/HDAC activity.
HO53 increases expressions of STAT3 and HIF1A, which are involved in CAMP expression in BCi cells.
HO53 treatment leads to changes in the expression of genes of the glycolysis and the TCA cycle.
HO53 induces a progressive change in the expression of important genes related to the metabolism in BCi cells (SLC2A4, GCKR, PFKP, ALDOB, PGAM2, PDK4, PDK2 and OGDHL).
| M.Wt | 410.43 | |
| Formula | C20H22N6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Barrier ML, et al. Mol Immunol. 2023 Mar;155:153-164.
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