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Chemical Structure : HPK inhibitor compound 1
Catalog No.: PC-38665Not For Human Use, Lab Use Only.
HPK inhibitor compound 1 is an allosteric, inactive conformation-selective HPK1 inhibitor, binds to unphosphorylated HPK1 and >24-fold more potently than active HPK1.
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HPK inhibitor compound 1 is an allosteric, inactive conformation-selective HPK1 inhibitor, binds to unphosphorylated HPK1 and >24-fold more potently than active HPK1.
HPK inhibitor compound 1 is not competitive with ATP, and is highly selective against kinases critical for T cell signaling.
HPK inhibitor compound 1 does not bind to the isolated HPK1 kinase domain alone but requires other domains, attenuates kinase autophosphorylation by binding to a pocket consisting of residues within and outside of the kinase domain.
| M.Wt | 412.443 | |
| Formula | C19H17FN6O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Weixue Wang, et al. Biochemistry. 2021 Oct 19;60(41):3114-3124.
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