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Chemical Structure : HPPE
CAS No.: 1325721-55-8
Catalog No.: PC-73337Not For Human Use, Lab Use Only.
HPPE is a specific nonelectrophilic and physiological Bach1 inhibitor via heme-binding sites of Bach1 protein, derepresses Bach1-mediated repression.
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|---|---|---|---|
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| 10 mg | $218 | In stock | |
| 25 mg | $378 | In stock | |
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HPPE is a specific nonelectrophilic and physiological Bach1 inhibitor via heme-binding sites of Bach1 protein, derepresses Bach1-mediated repression.
HPPE induces up-regulation of Hmox1 mRNA is mediated by Bach1 inhibition in vivo.
Nuclear export of Bach1 is required for HPPE-mediated Bach1 derepression, HPPE has an additional activity in Nrf2 stabilization besides Bach1 inhibition.
Pre- and posttreatment of HPPE is neuroprotective against acute MPTP neurotoxicity.
HPPE significantly reduced MPTP-induced increases in TNF-α and Mcp-1 mRNA levels, HPPE significantly increased mRNA levels of Nrf2 compared to MPTP-treated mice that received the vehicle.
Bach1 is a known transcriptional repressor of the Nrf2 pathway.
Bach1 ablation is cytoprotective, as it suppresses reactive oxygen species (ROS) generation, mitigates excessive inflammation, improves mitochondrial function, and inhibits apoptosis.
| M.Wt | 479.478 | |
| Formula | C21H20F3N5O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(2-(2-hydroxyethoxy)ethyl)-1-methyl-2-((6-(trifluoromethyl)benzo[d]thiazol-2-yl)amino)-1H-benzo[d]imidazole-5-carboxamide |
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1. Manuj Ahuja, et al. Proc Natl Acad Sci U S A. 2021 Nov 9;118(45):e2111643118.
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