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HQY1428

Chemical Structure : HQY1428

CAS No.: 3093763-71-1

HQY1428 (HQY-1428)

Catalog No.: PC-26145Not For Human Use, Lab Use Only.

HQY1428 is an oral availabile cyclin K molecular glue degrader, promotes CDK12 condensation in nuclear speckles and accelerates proteasomal degradation of CDK12-cyclin K, shows potent single-agent antitumor activity and synergistic efficacy with HER2 inhibitors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

HQY1428 is an oral availabile cyclin K molecular glue degrader, promotes CDK12 condensation in nuclear speckles and accelerates proteasomal degradation of CDK12-cyclin K, shows potent single-agent antitumor activity and synergistic efficacy with HER2 inhibitors.

Physicochemical Properties

M.Wt 547.05
Formula C25H28ClFN6O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-(3-amino-5-fluorophenyl)(3-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)piperidin-1-yl)methanone

References

1. Ye K, et al. bioRxiv, 2025: 2025.03. 31.646293.

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