Chemical Structure : HQY1428
CAS No.: 3093763-71-1
Catalog No.: PC-26145Not For Human Use, Lab Use Only.
HQY1428 is an oral availabile cyclin K molecular glue degrader, promotes CDK12 condensation in nuclear speckles and accelerates proteasomal degradation of CDK12-cyclin K, shows potent single-agent antitumor activity and synergistic efficacy with HER2 inhibitors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $248 | In stock | |
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HQY1428 is an oral availabile cyclin K molecular glue degrader, promotes CDK12 condensation in nuclear speckles and accelerates proteasomal degradation of CDK12-cyclin K, shows potent single-agent antitumor activity and synergistic efficacy with HER2 inhibitors.
| M.Wt | 547.05 | |
| Formula | C25H28ClFN6O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-(3-amino-5-fluorophenyl)(3-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)piperidin-1-yl)methanone |
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1. Ye K, et al. bioRxiv, 2025: 2025.03. 31.646293.

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