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Chemical Structure : HS-243
CAS No.: 848249-10-5
Catalog No.: PC-73131Not For Human Use, Lab Use Only.
HS-243 (HS243) is a highly potent, super-selective IRAK-1/4 inhibitor with IC50 of 24/20 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $498 | In stock | |
| 100 mg | $878 | In stock | |
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HS-243 (HS243) is a highly potent, super-selective IRAK-1/4 inhibitor with IC50 of 24/20 nM, respectively.
HS-243 shows exquisite potency toward IRAK-1/4 over all other human kinases with only minimal TAK1-inhibiting activity (IC50=0.5 uM).
HS-243 binds in the ATP-binding pocket of IRAK-4.
HS-243 potently reduces the proinflammatory response of RA cells and macrophages, has distinct cytokine profile from TAK1.
HS-243 reduces percentage of survival in pancreatic and breast cancer cell lines.
| M.Wt | 324.34 | |
| Formula | C17H16N4O3 | |
| Appearance | Solid | |
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1. Scarneo SA, et al. J Biol Chem. 2020 Feb 7;295(6):1565-1574.
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