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Chemical Structure : HS220
CAS No.: 1570374-32-1
Catalog No.: PC-35930Not For Human Use, Lab Use Only.
HS220 (HS-220) is a Plasmodium-selective takinib analog that targets atypical P. falciparum protein kinase 9 (PfPK9, Kd=4.1 uM) but does not inhibit HsTAK1, decreases K63-linked ubiquitination in P. falciparum.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $298 | In stock | |
| 10 mg | $428 | In stock | |
| 25 mg | $728 | In stock | |
| 100 mg | Get quote |
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HS220 (HS-220) is a Plasmodium-selective takinib analog that targets atypical P. falciparum protein kinase 9 (PfPK9, Kd=4.1 uM) but does not inhibit HsTAK1, decreases K63-linked ubiquitination in P. falciparum.
HS220 inhibits P. berghei parasite load in HuH7 cells with EC50 of 43 uM, with no significant change on HuH7 viability.
HS220 induce a unique phenotype where parasite size in hepatocytes increases.
| M.Wt | 323.352 | |
| Formula | C18H17N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-((1-propyl-1H-benzo[d]imidazol-2-yl)carbamoyl)benzoic acid |
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1. Raphemot R, et al. Cell Chem Biol. 2018 Nov 19. pii: S2451-9456(18)30391-X.
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